Articles in Press

Volume 1


Research Article

The Personalization of Cancer Cure: Reality or Illusion?

Giusy Messina*, Paolo Lissoni, Franco Rovelli, Fernando Brivio, Luca Fumagalli

It is known that the prognosis of the neoplastic diseases does not depend only on tumor characteristics, including lesion extension, histology and genetic profile, but also on the biological response of patients, which depends on both immune and endocrine variables, since the immune system is physiologicaliy under a psychoneuroendocrine regulation. Therefore, a synthetic clinical evaluation of the endocrine and immune functions either prior to the various anticancer therapies or under treatment is essential for realizing an adequate investigation of the mechanisms involved in the clinical course of the neoplastic disease.


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Case Report

Chronic Lymphocytic Leukemia, a Special Case Report

Aurelian Udristioiu*

Chronic lymphocytic leukemia, (CLL), is a heterogeneous disease, clinically characterized by the accumulation and expansion of a clone population of mature B lymphocytes in blood, bone marrow and lymphoid organs. Initially, genetic events are primarily responsible for the first stage of malignancy transformation and the processes of development and progression of CLL clone are considered to be modulated by signals of different micro-cellular environment, which regulates cell proliferation and survival of malignant B cells.


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