Effects of strength-based intervention on health outcomes of family caregivers of persons with dementia: A study protocol

Objective: This study aimed to identify the health effects of interventions based on the strength of family caregivers of people with dementia and to explore the underlying mechanisms. Perception-based family caregivers in the intervention force will also be explored.


Design: sequential mixed methods studies consists of a double-blind randomized controlled trials and qualitative descriptive study.


Methods: A group of 372 people with dementia family caregivers will be recruited from community settings. They will be randomized to receive the intervention or educational program based on the strength of dementia. Based on the theory of salutogenesis Antonovksy, integrated power-based intervention therapy skills and empowerment narrative strategy. It consists of 14 weekly group-based sessions and two bi-weekly follow-up phone calls. The education program serves as a control intervention. validated instrument used to measure the sense of coherence, coping, caregiver burden, and health-related quality-of-life at baseline, 14 weeks, and 22 weeks. Mixed-effects models and path analysis will be used to identify the effects of treatment and mediation mechanisms. A sub-sample of 30 caregivers reporting differential changes in health outcomes will be involved in the qualitative interviews. The study was funded in 2017.


Discussion: This study marks the first attempt to adopt a strength-based approach to theory-driven to improve the health outcomes of family caregivers of people with dementia. Rigorous and comprehensive evaluation will inform the effects and the underlying mechanism.


Impact: The study will have implications for public health and an important theoretical. Theoretically, this research will increase understanding about salutogenesis Antonovsky’s theory by examining the modifiability of a sense of coherence and ways to improve health-related outcomes. In terms of public health implications, strengths-based interventions focusing on optimizing the inner strength to provide a new paradigm for promoting adjustment of family caregivers of people with dementia.


trial registration: This project has been registered in Clinical Trials Registry of the Center for Clinical Research and Biostatistics.

Assessment of the Regulatory Dialogue Between Pharmaceutical Companies and the European Medicines Agency on the Choice of Noninferiority Margins
Assessment of the Regulatory Dialogue Between Pharmaceutical Companies and the European Medicines Agency on the Choice of Noninferiority Margins

Statistical problems in the development of a predictive model COVID-19

clinical prediction model for diagnosis help, assess the severity of the disease or the prognosis has great potential to assist clinical decision making during the 19th covid pandemic. A systematic review of life has, so far, identified 145 covid-19 prediction models published (or have already been printed) between 03-Jan-2020 and 05-may-2020.

Despite considerable interest in developing a model covid-19 predictions, review concluded that all models to date, without exception, are at high risk of bias by the concerns related to the quality of the data, weaknesses in statistical analysis and reporting was poor, and no recommended for use.

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Disappointingly, a recent study by Yang and colleagues describe the development of predictive models to identify covid 19 patients with severe disease, is no different. These studies have failed to report important information needed to assess the findings of the study, but had many methodological concerns in the design and analysis of viable highlights. This article is protected by copyright. All rights reserved.